Cost-effectiveness of quantitative hepatitis B virus surface antigen testing in pregnancy in predicting vertical transmission risk

Vertical transmission of hepatitis B virus (HBV) can occur despite immunoprophylaxis in mothers with high HBV DNA levels (>5-7 log10 IU/ml). Quantitative hepatitis B surface antigen (qHBsAg) testing could be used as a surrogate marker to identify high viral load carriers, but there is limited data in pregnancy. We conducted a prospective observational study to determine the cost-effectiveness and utility of qHBsAg as a valid surrogate marker of HBV DNA.


Year of Publication: 2016

Authors: Carla Coffin, Carmen L. Charlton, Eliana Castillo, Golasa Samadi Kochaksaraei, Stephen Congly, Steven R. Martin, Trudy Matwiy

Journal Title: Liver Int.