Evaluation of the effect of chickenpox vaccination on shingles epidemiology using agent-based modeling

Biological interactions between varicella (chickenpox) and herpes zoster (shingles), two diseases caused by the varicella zoster virus (VZV), continue to be debated including the potential effect on shingles cases following the introduction of universal childhood chickenpox vaccination programs. We investigated how chickenpox vaccination in Alberta impacts the incidence and age-distribution of shingles over 75 years post-vaccination, taking into consideration a variety of plausible theories of waning and boosting of immunity.

Year of Publication: 2018

Authors: Alexander Doroshenko, Ellen Rafferty, Nathaniel Osgood, Wade McDonald, Weichang Qian

Journal Title: PeerJ